Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds
نویسندگان
چکیده
منابع مشابه
Pathogenesis of Polymicrobial Biofilms
In polymicrobial biofilms a high level of interspecies interactions occur with often detrimental effect to the host. Many chronic infections are attributed to polymicrobial biofilms which tend to exhibit increased resistance to antimicrobial therapy. Yet despite the gravity of such infections, areas of study in polymicrobial diseases are in their infancy. Thus, much work is needed to promote a ...
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Bacterial biofilms present a significant medical challenge because they are recalcitrant to current therapeutic regimes. A key component of biofilm formation in the opportunistic human pathogen Pseudomonas aeruginosa is the biosynthesis of the exopolysaccharides Pel and Psl, which are involved in the formation and maintenance of the structural biofilm scaffold and protection against antimicrobi...
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ADP-ribosylation refers to the transfer of the ADP-ribose group from NAD(+) to target proteins post-translationally, either attached singly as mono(ADP-ribose) (MAR) or in polymeric chains as poly(ADP-ribose) (PAR). Though ADP-ribosylation is therapeutically important, investigation of this protein modification has been limited by a lack of proteomic tools for site identification. Recent work h...
متن کاملFungal Biofilms and Polymicrobial Diseases
Biofilm formation is an important virulence factor for pathogenic fungi. Both yeasts and filamentous fungi can adhere to biotic and abiotic surfaces, developing into highly organized communities that are resistant to antimicrobials and environmental conditions. In recent years, new genera of fungi have been correlated with biofilm formation. However, Candida biofilms remain the most widely stud...
متن کاملGlycoside Hydrolases across Environmental Microbial Communities
Across many environments microbial glycoside hydrolases support the enzymatic processing of carbohydrates, a critical function in many ecosystems. Little is known about how the microbial composition of a community and the potential for carbohydrate processing relate to each other. Here, using 1,934 metagenomic datasets, we linked changes in community composition to variation of potential for ca...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2017
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.01998-16